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What’s
DoxyPEP?

DoxyPEP involves taking an antibiotic called doxycycline. Taking this medicine after sex reduces the chance you’ll get a bacterial sexually transmitted infection.

DoxyPEP is not yet available through the NHS but surveys suggest up to 1 in 3 sexually active gay men have already used it. See below for more information and how to access it.

How well does it work?

Studies show that DoxyPEP reduces the chance of getting chlamydia & syphilis by around three-quarters and the risk of gonorrhoea by around half.  It gives no protection against any infections caused by viruses such as herpes, warts, HIV and hepatitis.

HOW DO YOU TAKE IT?

Take a 200mg dose of doxycycline within 72 hours after sex (2x100mg pills). Don’t take it more than once each day.

ARE THERE ANY POSSIBLE DOWNSIDES?

  • Some people worry that using doxycycline regularly might increase antibiotic resistance or affect the balance of healthy bacteria in your gut. Others argue that this is unlikely to be a problem because the drug is already given long-term for other health issues without it causing any problems. (e.g. acne treatment).

 

  • Doxycycline can make skin more sensitive to ultraviolet light, so be careful in the sun when taking it regularly. Take the pills standing up with plenty of water to reduce the chance of stomach irritation.

 

  • Doxycycline should not be used in pregnancy. Don’t take it at the same time as indigestion remedies. It has very few significant drug interactions. You can check its safe with any other medicines you take on the BNF website
BNF Website

How can I get it?

The NHS is currently developing DoxyPEP guidelines. It’s likely to be offered to selected groups of people by the end of 2024. In the meantime, there are other ways that people are accessing doxycycline.

Buy Online

Like HIV PrEP, it is legal to buy up to 3 month’s supply online for personal use. The online pharmacies listed on ‘I want PrEP now’ were independently verified to supply genuine HIV PrEP. The sites also sell Doxycycline. They are based outside the UK.

Buy from UK source

The team behind Prepster have developed this guide that includes information on getting Doxycycline from a UK based sources.

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